Genetic variations increasing the risk of lung cancer

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An international team of researchers has discovered two genetic variations that appear to be responsible for increasing the risk of lung cancer by about 60%. In April the same team has identified another gene "responsible" increase the risk of lung cancer, both for smokers and for non-smokers. "We are looking into the differences in DNA that make lung cancer more or less likely," said Paul Brennan, a researcher at the International Agency for Research of Cancer. The idea is that once discovered genes may be responsible for the causes leading to declansarea disease. Lung cancer is a principal reason for deaths in men and the second cause of death among women around the world, according to the American Society of Cancer Research (American Cancer Society). Smoking is definitely the main cause of trigger disease, but researchers want to know now, based on genetic research, why some long-term smokers never developed the disease, while it appears to people who do not smoke. The study, published in the journal Nature Genetics, included more than 15 000 people, 6 000 who had cancer lung and 9 000 people who were not diagnosed with the disease. Research studies have highlighted a region in the fifteenth chromosome, which contains two genes CRR9 and TERT - which is believed that their variations might trigger the disease by about 60%.
There is a little known about CRR9 gene, TERT gene is "promising", because it is known that it operates production enzyme called telomerasa, which apparently is the key processes of aging and cancer trigger - said Brennan. Cancer is generated by some "failure" of DNA; each time a cell division, chromosome ends are frayed progressively to cell death. But when cells become cancerous, it produces telomerasa, which regenerated chromosome ends, leading to the development of cells without control and, finally, the development of tumors. It is thus open the way for identification of substances to stop the development of tumors.

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